Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 10/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907742 | 1.00 | MAPKAPK2 (0.47) | MAPKAPK2HDAC1OPRK1CDK1CCNB2 | |
| SCHEMBL4898767 | 0.88 | RPS6KB1 (0.40) | CDK1CCNB2CCNB1CCNB3PLK4 | |
| SCHEMBL4900221 | 0.84 | MAPKAPK2 (0.47) | MAPKAPK2HDAC1OPRK1CDK1CCNB2 | |
| SCHEMBL4897972 | 0.84 | MAPKAPK2 (0.47) | MAPKAPK2HDAC1OPRK1CDK1CCNB2 | |
| SCHEMBL4598811 | 0.83 | MAPKAPK2 (0.61) | MAPKAPK2ROCK2CHEK2MAPK1GSK3B | |
| SCHEMBL4596962 | 0.83 | MAPKAPK2 (0.61) | MAPKAPK2ROCK2CHEK2MAPK1GSK3B | |
| SCHEMBL4598401 | 0.79 | KDR (0.47) | RPS6KB1KDRAURKB | |
| SCHEMBL4905587 | 0.79 | ROCK1 (0.48) | MAPKAPK2CDK1PLK4CHEK1DAPK3 | |
| SCHEMBL4598110 | 0.74 | MAPKAPK2 (0.49) | MAPKAPK2MAPK1ROCK1AURKBCYP2C9 | |
| SCHEMBL4905562 | 0.74 | KDR (0.44) | MAPKAPK2CDK1CCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | MAPKAPK2 346/4885HDAC1 1193/4885OPRK1 3286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.