Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 5/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898767 | 0.90 | RPS6KB1 (0.40) | KDRABL1NAMPTIP6K1AURKA | |
| SCHEMBL4596911 | 0.90 | NAMPT (0.47) | KDRABL1NAMPTQPCTIP6K1 | |
| SCHEMBL4905587 | 0.83 | ROCK1 (0.48) | KDRABL1NAMPTQPCTIP6K1 | |
| SCHEMBL4905562 | 0.82 | KDR (0.44) | KDRABL1QPCTF2PRSS1 | |
| SCHEMBL4905113 | 0.82 | AURKB (0.39) | KDRABL1NAMPTQPCTPOLB | |
| SCHEMBL4907244 | 0.81 | GSK3B (0.41) | KDRABL1IP6K1AURKAAURKB | |
| SCHEMBL4598825 | 0.79 | QPCT (0.47) | KDRNAMPTQPCTF2PRSS1 | |
| SCHEMBL4900151 | 0.79 | MAPKAPK2 (0.47) | KDRAURKBRPS6KB1 | |
| SCHEMBL4907742 | 0.79 | MAPKAPK2 (0.47) | KDRAURKBRPS6KB1 | |
| SCHEMBL14066719 | 0.77 | IP6K1 (0.55) | KDRNAMPTQPCTIP6K1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910312-A1 | QUADRATIC ACID II DERIVATIVES | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| WO-2007014608-A1 | QUADRATIC ACID II DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | claimed |