Sugi Predict

Sugi Predict / Compounds / SCHEMBL4900535

SCHEMBL4900535

SCHEMBL4900535

COC(=O)c1cc(S(=O)(=O)NCCc2nc(-c3ccc(C(F)(F)F)cc3)sc2C)cc(C)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 8/20 0.41
▸ LMNA P02545 4/20 0.41
▸ KDM4E B2RXH2 3/20 0.40
▸ POLB P06746 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ HSP90AA1 P07900 1/20 0.39
▸ CRHBP P24387 1/20 0.39
▸ CRHR2 Q13324 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ GAA P10253 2/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ PPARA Q07869 6/20 0.39
▸ PPARG P37231 3/20 0.38
▸ TP53 P04637 4/20 0.38
▸ S1PR1 P21453 1/20 0.38
▸ S1PR3 Q99500 1/20 0.38
▸ PPARD Q03181 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4895165 0.92 LMNA (0.40) MAPTLMNAKDM4EHTTSMN1; SMN2
SCHEMBL4907641 0.92 PPARA (0.46) MAPTLMNAKDM4EMEN1KMT2A
SCHEMBL4905529 0.91 MAPT (0.45) MAPTLMNAKDM4EPOLBHTT
SCHEMBL4895286 0.91 MAPT (0.42) MAPTLMNAKDM4EPOLBHTT
SCHEMBL4895407 0.91 MAPT (0.47) MAPTLMNAKDM4EPOLBMEN1
SCHEMBL4899685 0.90 MAPT (0.42) MAPTLMNAKDM4EPOLBHTT
SCHEMBL4901284 0.89 TP53 (0.44) MAPTLMNAKDM4EMEN1KMT2A
SCHEMBL4898005 0.89 MAPT (0.47) MAPTLMNAKDM4EHTTMEN1
SCHEMBL4900694 0.87 MAPT (0.44) MAPTLMNAKDM4EPOLBHTT
SCHEMBL4906334 0.87 MAPT (0.44) MAPTLMNAKDM4EPOLBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD MAPT 1858/4885LMNA 317/4885KDM4E 3750/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD MAPT 1786/4885LMNA 319/4885KDM4E 3834/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD MAPT 1786/4885LMNA 319/4885KDM4E 3834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.