Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908233 | 0.91 | MEN1 (0.45) | LMNAAKR1C3TP53ALDH1A1MAPK1 | |
| SCHEMBL4897950 | 0.83 | LMNA (0.60) | LMNAAKR1C3TP53ALDH1A1MAPT | |
| SCHEMBL5377000 | 0.83 | POLB (0.58) | LMNAMCL1ALDH1A1MAPK1KMT2A | |
| SCHEMBL4903791 | 0.82 | LMNA (0.61) | LMNAAKR1C3TP53ALDH1A1KMT2A | |
| SCHEMBL4909082 | 0.82 | AKR1C3 (0.62) | LMNAAKR1C3TP53ALDH1A1MAPK1 | |
| SCHEMBL4906406 | 0.81 | LMNA (0.57) | LMNAAKR1C3TP53ALDH1A1MAPK1 | |
| SCHEMBL4904104 | 0.81 | LMNA (0.57) | LMNAAKR1C3TP53ALDH1A1MAPK1 | |
| SCHEMBL4905692 | 0.80 | LMNA (0.56) | LMNAAKR1C3TP53ALDH1A1MAPK1 | |
| SCHEMBL4902838 | 0.80 | AKR1C3 (0.60) | LMNAAKR1C3TP53KMT2AMAPT | |
| SCHEMBL4905940 | 0.80 | LMNA (0.53) | LMNAAKR1C3TP53ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | LMNA 319/4885AKR1C3 1645/4885MCL1 4319/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | LMNA 319/4885AKR1C3 1645/4885MCL1 4319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.