Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 4/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 4/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801713 | 0.91 | CDK5 (0.61) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL17310488 | 0.88 | MAPK8 (0.55) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL4737479 | 0.88 | PLK1 (0.61) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL14088787 | 0.87 | JAK2 (0.59) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL4901211 | 0.87 | CDK5 (0.75) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL12801541 | 0.86 | JAK2 (0.56) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL1667153 | 0.86 | MEN1 (0.56) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL27898107 | 0.86 | MEN1 (0.56) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL4897612 | 0.86 | JAK2 (0.56) | MEN1KMT2ACDK5NPC1RAB9A | |
| SCHEMBL4903233 | 0.85 | JAK2 (0.65) | MEN1KMT2ACDK5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | claimed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | claimed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | claimed |
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | TYMP, TDP1, PNP | MEN1 3644/4885KMT2A 3738/4885CDK5 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.