Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.55 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 5/20 | 0.52 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254008 | 0.92 | MEN1 (0.60) | MAPK8CAMKK2PIK3CGCDK5MEN1 | |
| SCHEMBL14254021 | 0.91 | PIK3CG (0.56) | MAPK8CAMKK2PIK3CGCDK5MEN1 | |
| SCHEMBL14254003 | 0.91 | PIK3CG (0.60) | MAPK8CAMKK2PIK3CGCDK5MEN1 | |
| SCHEMBL14253972 | 0.90 | CAMKK2 (0.61) | MAPK8CAMKK2PIK3CGIKBKBJAK2 | |
| SCHEMBL14253977 | 0.89 | SYK (0.57) | MAPK8CAMKK2PIK3CGCDK5MEN1 | |
| SCHEMBL4901089 | 0.88 | MEN1 (0.62) | PIK3CGCDK5MEN1NPC1RAB9A | |
| SCHEMBL14254019 | 0.88 | CAMKK2 (0.53) | MAPK8CAMKK2PIK3CGSYKJAK2 | |
| SCHEMBL14254018 | 0.87 | CCNT1 (0.54) | MAPK8CAMKK2PIK3CGSYKIKBKB | |
| SCHEMBL14254012 | 0.85 | PIK3CG (0.66) | MAPK8CAMKK2PIK3CGCDK5MEN1 | |
| SCHEMBL14254013 | 0.85 | PIK3CG (0.57) | MAPK8CAMKK2PIK3CGCDK5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | TBK1, NFKBIA, CHUK | MAPK8 550/4885CAMKK2 809/4885PIK3CG 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.