Zopolrestat

Zopolrestat

SCHEMBL49012

O=C(O)Cc1nn(Cc2nc3cc(C(F)(F)F)ccc3s2)c(=O)c2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 20/20 1.00
AKR1B10 O60218 1/20 1.00
AKR1A1 P14550 1/20 1.00
GLO1 Q04760 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zopolrestat SCHEMBL29353641 1.00 AKR1B1 (1.00) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL8505122 1.00 AKR1B1 (1.00) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL8129027 0.99 AKR1B1 (0.98) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL7185596 0.95 AKR1B1 (0.90) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL7179887 0.93 AKR1B1 (0.87) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL7180777 0.93 AKR1B1 (0.87) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL15939730 0.92 AKR1B1 (0.84) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL7565103 0.92 AKR1B1 (0.84) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL8129830 0.91 AKR1B1 (0.83) AKR1B1AKR1B10AKR1A1GLO1
Zopolrestat SCHEMBL15939751 0.90 AKR1B1 (0.81) AKR1B1AKR1B10AKR1A1GLO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3491 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250177348-A1 Methods for Fructokinase Meditation of Alcohol Craving and Alcohol Induced Liver Disease THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 2025-06-05 US claimed
US-20240374693-A1 TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS UNIVERSITY OF ROCHESTER 2024-11-14 US claimed
US-12083168-B2 Treatment and detection of inherited neuropathies and associated disorders UNIVERSITY OF MIAMI (US) 2024-09-10 US claimed
WO-2024053761-A1 COMPOSITION FOR PROMOTING MYOBLAST PROLIFERATION AND DIFFERENTIATION CONTAINING ALDOSE REDUCTASE INHIBITOR 애니머스큐어 주식회사 2024-03-14 WO claimed
US-20240033263-A1 COMBINATION OF ALDOSE REDUCTASE INHIBITORS AND PROBENECID FOR THE TREATMENT OF DIABETIC COMPLICATIONS MYLARI Banavara (US) 2024-02-01 US claimed
US-20240003908-A1 POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2024-01-04 US claimed
US-20230346782-A1 COMPOSITIONS AND METHODS FOR TREATING GALACTOSEMIA BARCLAYS BANK PLC (GB) 2023-11-02 US claimed
US-20230293642-A9 TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS UNIVERSITY OF ROCHESTER 2023-09-21 US claimed
EP-4244243-A1 POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION Mayo Foundation for Medical Education and Research (US) 2023-09-20 EP claimed
US-20230058134-A1 ALDOSE REDUCTASE INHIBITORS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME, ACUTE LUNG INFLAMMATION/INJURY, CARDIAC INJURY AND ANTI-VIRAL THERAPY BARCLAYS BANK PLC (GB) 2023-02-23 US claimed
WO-1999002189-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALDOSE REDUCTASE INHIBITOR AND AN ACE INHIBITOR ZENECA LIMITED (GB) 1999-01-21 WO claimed
EP-0880964-A2 Aldose reductase inhibition in preventing or reversing diabetic cardiomyopathy PFIZER INC. (US) 1998-12-02 EP claimed
US-5834466-A ADMINISTERING ALDOSE REDUCTASE INHIBITOR, NICOTINIC ACID OR METHYLENE BLUE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-11-10 US claimed
WO-1998022114-A1 A METHOD FOR PROMOTING TISSUE REPAIR DUMEX-ALPHARMA A/S (DK) 1998-05-28 WO claimed
EP-0801569-A1 METHOD FOR PROTECTING THE HEART FROM ISCHEMIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-10-22 EP claimed
EP-0792643-A1 Use of an aldose reductase inhibitor for reducing non-cardiac tissue damage PFIZER INC. (US) 1997-09-03 EP claimed
WO-1996019225-A9 METHOD FOR PROTECTING THE HEART FROM ISCHEMIA 1996-09-19 WO claimed
WO-1996019225-A1 METHOD FOR PROTECTING THE HEART FROM ISCHEMIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-06-27 WO claimed
US-5391551-A Method of lowering blood lipid levels PFIZER INC. (US) 1995-02-21 US claimed
EP-0624369-A1 Method of lowering blood lipid levels PFIZER INC. (US) 1994-11-17 EP claimed