Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 0.84 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.84 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.84 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zopolrestat SCHEMBL49012 | 0.92 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL8505122 | 0.92 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL29353641 | 0.92 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL8129027 | 0.91 | AKR1B1 (0.98) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL7185596 | 0.87 | AKR1B1 (0.90) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL7180777 | 0.85 | AKR1B1 (0.87) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL7179887 | 0.85 | AKR1B1 (0.87) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL15939730 | 0.84 | AKR1B1 (0.84) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL8129830 | 0.83 | AKR1B1 (0.83) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Zopolrestat SCHEMBL15939751 | 0.83 | AKR1B1 (0.81) | AKR1B1AKR1B10AKR1A1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224179-A2 | SODIUM-HYDROGEN EXCHANGER TYPE 1 INHIBITOR CRYSTALS | Pfizer Products Inc. (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030759-A2 | SODIUM-HYDROGEN EXCHANGER TYPE 1 INHIBITOR CRYSTALS | PFIZER PRODUCTS INC. (US) | 2001-05-03 | — | — | WO | disclosed |