Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 16/20 | 0.54 |
| ▸ | BCR | P11274 | 12/20 | 0.54 |
| ▸ | KIT | P10721 | 7/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.50 |
| ▸ | ABL2 | P42684 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | DDX3X | O00571 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905299 | 0.92 | SMN1; SMN2 (0.56) | ALDH1A1LMNATSHRABL1BCR | |
| SCHEMBL4897520 | 0.91 | ABL1 (0.67) | LMNAABL1BCRKITPDGFRB | |
| SCHEMBL4903720 | 0.90 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4ETSHRHRH2 | |
| SCHEMBL4903153 | 0.89 | ABL1 (0.63) | LMNAABL1BCRKITPDGFRB | |
| SCHEMBL4901676 | 0.88 | JAK2 (0.54) | ALDH1A1LMNAKDM4ETSHRABL1 | |
| SCHEMBL4892565 | 0.88 | ABL1 (0.54) | LMNAKDM4EABL1BCRKIT | |
| SCHEMBL4903273 | 0.88 | ALDH1A1 (0.54) | ALDH1A1LMNAKDM4ETSHRABL1 | |
| SCHEMBL4900880 | 0.86 | ABL1 (0.54) | LMNAABL1BCRKITPDGFRB | |
| SCHEMBL4892416 | 0.81 | ABL1 (0.63) | LMNAABL1BCRKITPDGFRB | |
| SCHEMBL4901605 | 0.81 | ABL1 (0.62) | ABL1BCRPDGFRBPDGFRAABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | claimed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | claimed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | claimed |
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | disclosed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | TYMP, TDP1, PNP | ALDH1A1 376/4885LMNA 1955/4885KDM4E 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.