Tandospirone

Tandospirone

SCHEMBL49026

O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1CCCCN1CCN(c2ncccn2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 1.00
HTR1A P08908 1/20 1.00
DRD4 P21917 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tandospirone SCHEMBL4445506 1.00 DRD2 (1.00) DRD2HTR1ADRD4
Tandospirone SCHEMBL13532602 1.00 DRD2 (1.00) DRD2HTR1ADRD4
Tandospirone SCHEMBL22693814 1.00 DRD2 (1.00) DRD2HTR1ADRD4
Tandospirone SCHEMBL22381099 1.00 DRD2 (1.00) DRD2HTR1ADRD4
Tandospirone SCHEMBL16339864 0.99 DRD2 (1.00) DRD2HTR1ADRD4
Tandospirone SCHEMBL1766255 0.99 DRD2 (1.00) DRD2HTR1ADRD4
SCHEMBL10925913 0.95 DRD2 (0.90) DRD2HTR1ADRD4
Hydrochloric Acid SCHEMBL11011731 0.94 DRD2 (0.91) DRD2HTR1ADRD4
Tandospirone SCHEMBL15383602 0.92 DRD2 (0.85) DRD2HTR1ADRD4
Tandospirone SCHEMBL15383590 0.92 DRD2 (0.84) DRD2HTR1ADRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4327 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636259-B2 Transdermal absorption preparation Sumitomo Pharma Co., Ltd. (JP) 2026-05-26 US claimed
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO claimed
US-12350379-B2 Extended release pharmaceutical formulation and methods of treatment DOUGLAS PHARMACETICALS LTD (NZ) 2025-07-08 US claimed
US-20250213593-A1 Use of Derivatives based on Sarsasapogenin Structure and Pharmaceutical Compositions thereof BEIJING PHYTOVENT PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2025-07-03 US claimed
EP-4570250-A2 COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER Otsuka Pharmaceutical Co., Ltd. (JP) 2025-06-18 EP claimed
US-20250177385-A1 COMBINATIONS COMPRISING BREXPIPRAZOLE OR A SALT THEREOF AND A SECOND DRUG FOR USE IN THE TREATMENT OF A CNS DISORDER OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-06-05 US claimed
CN-119896653-A Percutaneous absorption preparation 湖南慧泽生物医药科技有限公司 2025-04-29 CN claimed
CN-116283926-B Preparation method of tandospirone citrate and application of tandospirone citrate in preparation 重庆圣华曦药业股份有限公司 2025-02-25 CN claimed
CN-119438406-A Detection method of related substances in tandospirone citrate 四川科瑞德制药股份有限公司 2025-02-14 CN claimed
US-5688518-A Antidepressive therapy ALZA CORPORATION (US) 1997-11-18 US claimed
WO-1997041878-A1 TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO claimed
EP-0510837-B1 Synergistic combinations in the treatment of anxiety PFIZER (US) 1997-09-03 EP claimed
EP-0681473-A1 COMPOSITIONS CONTAINING TANDOSPIRONE OR ITS ANALOGS ALZA CORPORATION (US) 1995-11-15 EP claimed
WO-1994016699-A1 COMPOSITIONS CONTAINING TANDOSPIRONE OR ITS ANALOGS ALZA CORPORATION (US) 1994-08-04 WO claimed
US-5330762-A Tandospiaine antidepressive therapy ALZA CORPORATION (US) 1994-07-19 US claimed
US-5246710-A Dosage form for treating cyclothymia ALZA CORPORATION (US) 1993-09-21 US claimed
US-5246711-A Dosage form for treating dysthymia ALZA CORPORATION (US) 1993-09-21 US claimed
US-5185158-A Dosage form comprising succinimide drug for treating depressive disorders and composition comprising same ALZA CORPORATION (US) 1993-02-09 US claimed
EP-0510837-A2 Synergistic combinations in the treatment of anxiety PFIZER INC. (US) 1992-10-28 EP claimed