Sugi Predict

Sugi Predict / Compounds / SCHEMBL4902834

SCHEMBL4902834

SCHEMBL4902834

COC(=O)c1cc(S(=O)(=O)NCCc2nc3cc(C)ccc3o2)cc(C)c1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 1/20 0.40
▸ AGPAT2 O15120 3/20 0.37
▸ MAPT P10636 3/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ GAA P10253 2/20 0.37
▸ GLA P06280 1/20 0.37
▸ RAB9A P51151 4/20 0.36
▸ NPC1 O15118 3/20 0.36
▸ RXFP1 Q9HBX9 1/20 0.36
▸ PTPN2 P17706 2/20 0.36
▸ PTPN1 P18031 2/20 0.36
▸ PTPN5 P54829 2/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ ALDH1A1 P00352 1/20 0.35
▸ TP53 P04637 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ THRB P10828 1/20 0.35
▸ HSPD1 P10809 1/20 0.35
▸ HSPE1 P61604 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4904004 0.91 MEN1 (0.43) AGPAT2MAPTMEN1KMT2ATP53
SCHEMBL4903610 0.90 KDR (0.41) KDRAGPAT2MAPTKDM4EGAA
SCHEMBL4906354 0.90 KDR (0.42) KDRAGPAT2MAPTKDM4EGAA
SCHEMBL4899747 0.86 KDR (0.43) KDRMAPTKDM4EGAAGLA
SCHEMBL4897492 0.85 KDR (0.45) KDRAGPAT2MAPTKDM4EGAA
SCHEMBL4895604 0.84 NPC1 (0.40) KDRMAPTKDM4EGAAGLA
SCHEMBL4903825 0.82 LMNA (0.50) KDRKDM4EALDH1A1TP53POLB
SCHEMBL4902731 0.81 MEN1 (0.44) AGPAT2MAPTMEN1KMT2ATP53
SCHEMBL4895991 0.81 KMT2A (0.44) AGPAT2MAPTGAARAB9ANPC1
SCHEMBL4906063 0.80 LMNA (0.45) MAPTKDM4EGAARAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD KDR 1168/4885AGPAT2 702/4885MAPT 1858/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD KDR 1143/4885AGPAT2 641/4885MAPT 1786/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD KDR 1143/4885AGPAT2 641/4885MAPT 1786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.