Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | CCND2 | P30279 | 2/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891073 | 0.90 | CTSC (0.40) | CDK4CCND1CCND3CDK6TTK | |
| SCHEMBL4901213 | 0.89 | CTSC (0.47) | CDK4CCND1CCND3MAP4K1CDK6 | |
| SCHEMBL4894058 | 0.89 | CTSC (0.40) | CDK4CCND1CCND3TYK2CDK6 | |
| SCHEMBL4900781 | 0.87 | CYP1A1 (0.50) | CDK4CCND1CCND3CDK6CTSC | |
| Hydrochloric Acid SCHEMBL4904505 | 0.86 | CDK4 (0.44) | CDK4CCND1CCND3CDK6ALK | |
| Hydrochloric Acid SCHEMBL4901468 | 0.86 | CDK4 (0.43) | CDK4CCND1CCND3CDK6PLK1 | |
| SCHEMBL5255881 | 0.85 | CTSC (0.45) | CDK4CCND1CCND3CDK6CTSC | |
| SCHEMBL5257505 | 0.84 | CDK4 (0.45) | CDK4CCND1CDK6 | |
| Hydrochloric Acid SCHEMBL4892307 | 0.83 | CDK4 (0.44) | CDK4CCND1CDK6 | |
| Hydrochloric Acid SCHEMBL4896584 | 0.83 | GHSR (0.49) | CDK4CCND1CCND2CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | CDK4 2754/4885CCND1 4529/4885CCND2 4524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.