Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 16/20 | 0.70 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 12/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903465 | 1.00 | BCL2L1 (0.70) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL5741850 | 0.91 | BCL2L1 (0.68) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL2952163 | 0.90 | BCL2L1 (0.72) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL1957631 | 0.90 | BCL2L1 (0.72) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL2945668 | 0.90 | BCL2L1 (0.72) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL1957630 | 0.90 | BCL2L1 (0.72) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL1959862 | 0.88 | BCL2L1 (0.75) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL1959864 | 0.88 | BCL2L1 (0.75) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL2951319 | 0.87 | BCL2L1 (0.74) | BCL2L1DOT1LBCL2MAPTPOLB | |
| SCHEMBL4737868 | 0.85 | BCL2L1 (0.78) | BCL2L1DOT1LBCL2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | BCL2L1 358/4885DOT1L 140/4885BCL2 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.