Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.81 |
| ▸ | KDR | P35968 | 20/20 | 0.81 |
| ▸ | IGF1R | P08069 | 19/20 | 0.81 |
| ▸ | MST1R | Q04912 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354420 | 0.92 | MET (0.81) | METKDRIGF1R | |
| SCHEMBL783420 | 0.90 | MET (1.00) | METKDRIGF1RMST1R | |
| SCHEMBL4903552 | 0.86 | MET (0.83) | METKDRIGF1RMST1R | |
| SCHEMBL198584 | 0.85 | MET (1.00) | METKDRIGF1RMST1R | |
| SCHEMBL198400 | 0.85 | MET (1.00) | METKDRIGF1RMST1R | |
| SCHEMBL201049 | 0.84 | MET (0.87) | METKDRIGF1RMST1R | |
| SCHEMBL199470 | 0.84 | MET (0.87) | METKDRIGF1RMST1R | |
| SCHEMBL200685 | 0.84 | MET (0.91) | METKDRIGF1RMST1R | |
| SCHEMBL197413 | 0.84 | MET (1.00) | METKDRIGF1RMST1R | |
| SCHEMBL198809 | 0.84 | MET (1.00) | METKDRIGF1RMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | claimed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | claimed |