Sugi Predict

Sugi Predict / Compounds / SCHEMBL4903732

SCHEMBL4903732

SCHEMBL4903732

CCc1ccc(S(=O)(=O)N(Br)CC)cc1C(=O)OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.55
▸ TSHR P16473 4/20 0.55
▸ HPGD P15428 3/20 0.40
▸ CA2 P00918 3/20 0.40
▸ KDM4E B2RXH2 3/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ HSD17B10 Q99714 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ LMNA P02545 5/20 0.37
▸ MAPT P10636 3/20 0.37
▸ GAA P10253 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ ADRA2A P08913 1/20 0.36
▸ CYP2D6 P10635 1/20 0.36
▸ CYP2C9 P11712 1/20 0.36
▸ DRD2 P14416 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4900658 0.86 ALDH1A1 (0.55) ALDH1A1TSHRHPGDCA2KDM4E
SCHEMBL4895946 0.85 ALDH1A1 (0.56) ALDH1A1TSHRHPGDCA2KDM4E
SCHEMBL4903747 0.79 ESR1 (0.60) ALDH1A1TSHRHPGDKDM4EHSD17B10
SCHEMBL4897962 0.79 ALDH1A1 (0.51) ALDH1A1TSHRHPGDCA2KDM4E
SCHEMBL4902250 0.78 ALDH1A1 (0.46) ALDH1A1TSHRHPGDCA2KDM4E
SCHEMBL4900071 0.78 ALDH1A1 (0.49) ALDH1A1TSHRHPGDCA2KDM4E
SCHEMBL4902984 0.76 ALDH1A1 (0.50) ALDH1A1TSHRKMT2ASMN1; SMN2LMNA
SCHEMBL4903725 0.75 MAPK1 (0.46) ALDH1A1TSHRKDM4EKMT2ACYP2C19
SCHEMBL4906234 0.74 ALDH1A1 (0.46) ALDH1A1TSHRHPGDCA2KDM4E
SCHEMBL4902927 0.74 ALDH1A1 (0.48) ALDH1A1TSHRHPGDCA2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 — — EP disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 — — WO disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD ALDH1A1 2664/4885TSHR 412/4885HPGD 696/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD ALDH1A1 2956/4885TSHR 400/4885HPGD 724/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD ALDH1A1 2956/4885TSHR 400/4885HPGD 724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.