Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.62 |
| ▸ | PDE4A | P27815 | 9/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.62 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | SELE | P16581 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14281568 | 0.89 | HSP90AB1 (0.56) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4911693 | 0.86 | HSP90AB1 (0.62) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907993 | 0.83 | BRAF (0.65) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4908426 | 0.83 | HSP90AB1 (0.61) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907235 | 0.83 | HSP90AB1 (0.56) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907703 | 0.83 | HSP90AB1 (0.59) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3321292 | 0.82 | HSP90AB1 (0.68) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4911642 | 0.80 | HSP90AB1 (0.57) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14466579 | 0.80 | BRAF (0.66) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4924193 | 0.77 | BRAF (1.00) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | PDE4A, PDE4B, BRAF | BRAF 3/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.