⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5152679 | 0.78 | — | — | |
| SCHEMBL14122608 | 0.78 | CHRM2 (0.39) | — | |
| SCHEMBL4890797 | 0.75 | BTK (0.31) | — | |
| SCHEMBL7423912 | 0.75 | BTK (0.31) | — | |
| SCHEMBL14122626 | 0.71 | CHRM3 (0.34) | — | |
| SCHEMBL5153248 | 0.70 | PPM1D (0.31) | — | |
| SCHEMBL6488743 | 0.70 | BTK (0.33) | — | |
| SCHEMBL6320796 | 0.70 | BTK (0.31) | — | |
| SCHEMBL2434403 | 0.70 | BTK (0.31) | — | |
| SCHEMBL4011681 | 0.69 | HPGD (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | disclosed |
| US-20080103311-A1 | Retroviral protease inhibitors | PHARMACIA CORPORATION (US) | 2008-05-01 | — | — | US | disclosed |
| US-7312333-B2 | Retroviral protease inhibitors | PHARMACIA CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| US-20070015818-A1 | Cyclic sulfone containing retroviral protease inhibitors | G.D. Searle & Co. (now G.D. Searle, LLC) (US) | 2007-01-18 | — | — | US | disclosed |
| US-7112683-B2 | Cyclic sulfone containing retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-09-26 | — | — | US | disclosed |
| US-20060166895-A1 | Retroviral protease inhibitors | MONSANTO COMPANY (NOW NAMED PHARMACIA CORPORATION, WHICH IS A WHOLLY OWNED SUBSIDIARY OF PFIZER, INC (US) | 2006-07-27 | — | — | US | disclosed |
| US-7026485-B2 | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-04-11 | — | — | US | disclosed |
| US-7026333-B1 | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2006-04-11 | — | — | US | disclosed |
| US-20060040974-A1 | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-02-23 | — | — | US | disclosed |
| US-20050119257-A1 | cyclic thiophene or thiopyran sulfone- and either urea- or N-heterocyclic moiety-containing hydroxyethylamine; mimetic compound binds to the enzyme; HIV virus | G.D. SEARLE & CO. (US) | 2005-06-02 | — | — | US | disclosed |
| US-5849784-A | Cyclic sulfone containing retroviral protease inhibitors | GD SEARLE & CO. (US) | 1998-12-15 | — | — | US | disclosed |
| US-5756534-A | Retroviral protease inhibitors | MONSANTO COMPANY (US) | 1998-05-26 | — | — | US | disclosed |
| US-5648364-A | HETEROCYCLIC PEPTIDE COMPOUNDS AS ENZYME INHIBITORS | MONSANTO COMPANY (US) | 1997-07-15 | — | — | US | disclosed |
| US-5643924-A | Retroviral protease inhibitors | MONSANTO COMPANY OF ST. LOUIS (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0677048-B1 | CYCLIC SULFONE CONTAINING RETROVIRAL PROTEASE INHIBITORS | SEARLE & CO (US) | 1997-01-22 | — | — | EP | disclosed |
| US-5514801-A | TREATMENT OF AIDS | MONSANTO COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0677048-A1 | CYCLIC SULFONE CONTAINING RETROVIRAL PROTEASE INHIBITORS. | SEARLE & CO (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0641325-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994014793-A1 | CYCLIC SULFONE CONTAINING RETROVIRAL PROTEASE INHIBITORS | G. D. SEARLE & CO. (US) | 1994-07-07 | — | — | WO | disclosed |
| WO-1993023379-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1993-11-25 | — | — | WO | disclosed |