Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423912 | 1.00 | BTK (0.31) | BTKGPR119GAA | |
| SCHEMBL6488743 | 0.91 | BTK (0.33) | BTKGPR119GAA | |
| SCHEMBL5152679 | 0.80 | — | — | |
| SCHEMBL14122608 | 0.80 | CHRM2 (0.39) | — | |
| SCHEMBL14122626 | 0.75 | CHRM3 (0.34) | BTK | |
| SCHEMBL4904084 | 0.75 | — | — | |
| SCHEMBL2434403 | 0.75 | BTK (0.31) | BTK | |
| SCHEMBL6320796 | 0.75 | BTK (0.31) | BTK | |
| SCHEMBL14122785 | 0.74 | CTSK (0.35) | GPR119 | |
| SCHEMBL4011681 | 0.73 | HPGD (0.30) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080103311-A1 | Retroviral protease inhibitors | PHARMACIA CORPORATION (US) | 2008-05-01 | — | — | US | disclosed |
| US-7312333-B2 | Retroviral protease inhibitors | PHARMACIA CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| US-20070015818-A1 | Cyclic sulfone containing retroviral protease inhibitors | G.D. Searle & Co. (now G.D. Searle, LLC) (US) | 2007-01-18 | — | — | US | disclosed |
| US-7112683-B2 | Cyclic sulfone containing retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-09-26 | — | — | US | disclosed |
| US-20060166895-A1 | Retroviral protease inhibitors | MONSANTO COMPANY (NOW NAMED PHARMACIA CORPORATION, WHICH IS A WHOLLY OWNED SUBSIDIARY OF PFIZER, INC (US) | 2006-07-27 | — | — | US | disclosed |
| US-7026485-B2 | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-04-11 | — | — | US | disclosed |
| US-7026333-B1 | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2006-04-11 | — | — | US | disclosed |
| US-20060040974-A1 | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-02-23 | — | — | US | disclosed |
| US-20050119257-A1 | cyclic thiophene or thiopyran sulfone- and either urea- or N-heterocyclic moiety-containing hydroxyethylamine; mimetic compound binds to the enzyme; HIV virus | G.D. SEARLE & CO. (US) | 2005-06-02 | — | — | US | disclosed |
| US-6875790-B2 | Cyclic sulfone containing retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2005-04-05 | — | — | US | disclosed |
| US-5849784-A | Cyclic sulfone containing retroviral protease inhibitors | GD SEARLE & CO. (US) | 1998-12-15 | — | — | US | disclosed |
| US-5756534-A | Retroviral protease inhibitors | MONSANTO COMPANY (US) | 1998-05-26 | — | — | US | disclosed |
| US-5648364-A | HETEROCYCLIC PEPTIDE COMPOUNDS AS ENZYME INHIBITORS | MONSANTO COMPANY (US) | 1997-07-15 | — | — | US | disclosed |
| US-5643924-A | Retroviral protease inhibitors | MONSANTO COMPANY OF ST. LOUIS (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0677048-B1 | CYCLIC SULFONE CONTAINING RETROVIRAL PROTEASE INHIBITORS | SEARLE & CO (US) | 1997-01-22 | — | — | EP | disclosed |
| US-5514801-A | TREATMENT OF AIDS | MONSANTO COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0677048-A1 | CYCLIC SULFONE CONTAINING RETROVIRAL PROTEASE INHIBITORS. | SEARLE & CO (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0641325-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994014793-A1 | CYCLIC SULFONE CONTAINING RETROVIRAL PROTEASE INHIBITORS | G. D. SEARLE & CO. (US) | 1994-07-07 | — | — | WO | disclosed |
| WO-1993023379-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1993-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103311-A1 | Retroviral protease inhibitors | PREP, DNPEP, SERPINB1 | BTK 3841/4885GPR119 4367/4885GAA 126/4885 |
| US-20060040974-A1 | Retroviral protease inhibitors | PREP, TMPRSS15, DNPEP | BTK 4319/4885GPR119 3803/4885GAA 220/4885 |
| US-20050119257-A1 | cyclic thiophene or thiopyran sulfone- and either urea- or N-heterocyclic moiety-containing hydroxyethylamine; mimetic compound binds to the enzyme; HIV virus | DNPEP, ANPEP, SPR | BTK 2764/4885GPR119 3436/4885GAA 742/4885 |
| US-20070015818-A1 | Cyclic sulfone containing retroviral protease inhibitors | TMPRSS15, TMPRSS11D, MME | BTK 2561/4885GPR119 3731/4885GAA 435/4885 |
| US-20060166895-A1 | Retroviral protease inhibitors | MME, PREP, TMPRSS15 | BTK 4387/4885GPR119 3764/4885GAA 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.