Sugi Predict

Sugi Predict / Compounds / SCHEMBL4904425

SCHEMBL4904425

SCHEMBL4904425

Cc1ccc(S(=O)(=O)NCCc2nc3cc(-c4ccccc4)ccc3o2)cc1C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.52
▸ ALDH1A1 P00352 1/20 0.42
▸ LIPG Q9Y5X9 1/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.41
▸ GAA P10253 1/20 0.41
▸ CETP P11597 1/20 0.41
▸ PTPN2 P17706 3/20 0.41
▸ PTPN1 P18031 3/20 0.41
▸ PTPN5 P54829 3/20 0.41
▸ TP53 P04637 1/20 0.40
▸ FBP1 P09467 1/20 0.40
▸ UTRN P46939 1/20 0.40
▸ ACLY P53396 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ USP30 Q70CQ3 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4897479 0.93 LMNA (0.43) LMNAALDH1A1LIPGL3MBTL1GAA
SCHEMBL4899808 0.89 LMNA (0.56) LMNAALDH1A1TP53POLBMAPT
SCHEMBL4903825 0.89 LMNA (0.50) LMNAALDH1A1L3MBTL1TP53KDM4E
SCHEMBL4898285 0.87 LMNA (0.48) LMNAGAATP53FBP1MAPT
SCHEMBL4894352 0.85 LMNA (0.47) LMNAALDH1A1L3MBTL1PTPN5TP53
SCHEMBL4903790 0.83 LMNA (0.52) LMNAALDH1A1PTPN2PTPN1PTPN5
SCHEMBL4905428 0.83 LMNA (0.48) LMNAALDH1A1L3MBTL1PTPN2PTPN1
SCHEMBL4906063 0.81 LMNA (0.45) LMNAALDH1A1GAATP53KDM4E
SCHEMBL4905719 0.80 LMNA (0.45) LMNAALDH1A1PTPN2PTPN1PTPN5
SCHEMBL4906354 0.80 KDR (0.42) LMNAALDH1A1GAAPTPN2PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885ALDH1A1 2664/4885LIPG 55/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885LIPG 43/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885LIPG 43/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.