Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897462 | 0.94 | HCRTR2 (0.51) | HCRTR2NR3C1LMNATRPM8SERPINE1 | |
| SCHEMBL4904184 | 0.91 | HCRTR2 (0.50) | HCRTR2NR3C1LMNATRPM8SERPINE1 | |
| SCHEMBL4906301 | 0.90 | HDAC8 (0.51) | LMNAMCL1MAPK1BCL2L1ESR1 | |
| SCHEMBL4907142 | 0.89 | HCRTR2 (0.54) | HCRTR2NR3C1LMNATRPM8SERPINE1 | |
| SCHEMBL4906264 | 0.89 | LMNA (0.52) | NR3C1LMNAMCL1MAPK1BCL2L1 | |
| SCHEMBL4903991 | 0.89 | LMNA (0.54) | NR3C1LMNAMCL1BCL2L1ESR1 | |
| SCHEMBL4895629 | 0.87 | LMNA (0.49) | NR3C1LMNAMCL1BCL2L1ESR1 | |
| SCHEMBL4900633 | 0.87 | LMNA (0.47) | LMNAMCL1BCL2L1ESR1ALDH1A1 | |
| SCHEMBL4897505 | 0.86 | LMNA (0.54) | LMNAMCL1BCL2L1ESR1ALDH1A1 | |
| SCHEMBL4905211 | 0.86 | LMNA (0.46) | LMNAMCL1BCL2L1ESR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | HCRTR2 3933/4885NR3C1 169/4885LMNA 319/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | HCRTR2 3933/4885NR3C1 169/4885LMNA 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.