Trinitrotoluene

Trinitrotoluene

SCHEMBL4904689

Cc1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-].Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.60

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.60
TSHR P16473 6/20 0.60
TDP1 Q9NUW8 4/20 0.60
CYP3A4 P08684 4/20 0.55
RECQL P46063 1/20 0.55
GPR35 Q9HC97 3/20 0.53
TP53 P04637 1/20 0.52
HPGD P15428 1/20 0.52
MAPK1 P28482 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HIF1A Q16665 1/20 0.52
TXNRD1 Q16881 1/20 0.50
TXNRD3 Q86VQ6 1/20 0.50
TXNRD2 Q9NNW7 1/20 0.50
HSD17B10 Q99714 2/20 0.47
PDE2A O00408 1/20 0.46
PDE5A O76074 1/20 0.46
ALOX15 P16050 1/20 0.46
NFKB1 P19838 1/20 0.46
APEX1 P27695 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trinitrotoluene SCHEMBL4908349 0.93 TSHR (0.55) ALDH1A1TSHRTDP1CYP3A4RECQL
SCHEMBL48806 0.92 ALDH1A1 (0.69) ALDH1A1TSHRTDP1CYP3A4RECQL
SCHEMBL29349558 0.92 ALDH1A1 (0.69) ALDH1A1TSHRTDP1CYP3A4RECQL
SCHEMBL9737090 0.90 ALDH1A1 (0.67) ALDH1A1TSHRTDP1CYP3A4RECQL
SCHEMBL9737083 0.90 ALDH1A1 (0.67) ALDH1A1TSHRTDP1CYP3A4RECQL
SCHEMBL28282548 0.89 TDP1 (0.66) ALDH1A1TSHRTDP1CYP3A4RECQL
Trinitrotoluene SCHEMBL20676 0.86 ALDH1A1 (0.61) ALDH1A1TSHRTDP1CYP3A4RECQL
Trinitrotoluene SCHEMBL891182 0.86 ALDH1A1 (0.61) ALDH1A1TSHRTDP1CYP3A4RECQL
O-Xylene SCHEMBL11165789 0.85 TSHR (0.66) ALDH1A1TSHRTDP1CYP3A4RECQL
Dinitrophenylene SCHEMBL17418136 0.85 TSHR (0.63) ALDH1A1TSHRTDP1CYP3A4RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109564181-A Electrochemical Detection containing nitro compound 拉莫特特拉维夫大学有限公司 2019-04-02 CN disclosed
US-9706755-B2 Controlled odor mimic permeation system FLORIDA INTERNATIONAL (US) 2017-07-18 US disclosed
US-20080295783-A1 Controlled Odor Mimic Permeation System THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2008-12-04 US disclosed