Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.66 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.66 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.66 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2387810 | 0.94 | RXRA (0.69) | RXRANR1H2NR1H3RIPK3ERAP1 | |
| SCHEMBL14214340 | 0.87 | RXRA (0.75) | RXRANR1H2NR1H3RIPK3MAPT | |
| SCHEMBL2386380 | 0.87 | RXRA (0.69) | RXRANR1H2NR1H3RIPK3MAPT | |
| SCHEMBL2390043 | 0.87 | RXRA (0.57) | RXRANR1H2NR1H3RIPK3MAPT | |
| SCHEMBL2385106 | 0.86 | RXRA (0.61) | RXRANR1H2NR1H3RIPK3MAPT | |
| SCHEMBL4897364 | 0.86 | NR1H2 (0.48) | RXRANR1H2NR1H3ERAP1MAPT | |
| SCHEMBL2390432 | 0.86 | RXRA (0.61) | RXRANR1H2NR1H3RIPK3MAPK14 | |
| SCHEMBL2391504 | 0.86 | RXRA (0.61) | RXRANR1H2NR1H3MAPTMAPK14 | |
| SCHEMBL5793484 | 0.85 | RXRA (0.70) | RXRANR1H2NR1H3MAPTMAPK14 | |
| SCHEMBL2387495 | 0.85 | NR1H2 (0.73) | RXRANR1H2NR1H3RIPK3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119488-A1 | Modulators Of Nuclear Receptors | EXELIXIS, INC. (US) | 2008-05-22 | — | — | US | disclosed |
| US-20080119488-A1 | Modulators Of Nuclear Receptors | EXELIXIS, INC. (US) | 2008-05-22 | — | — | US | disclosed |
| US-20080119488-A1 | Modulators Of Nuclear Receptors | EXELIXIS, INC. (US) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119488-A1 | Modulators Of Nuclear Receptors | NR1H2, NR0B1, NR1H3 | RXRA 20/4885NR1H2 1/4885NR1H3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.