Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Epalrestat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 known ✓ | P15121 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | AKR1A1 | P14550 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Epalrestat SCHEMBL1649205 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL17223887 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL6679566 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL49048 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL27969659 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL27969660 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL29229735 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL28070020 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL1331526 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL27969621 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6136 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4719592-A1 | BICYCLIC COMPOUNDS FOR KETOHEXOKINASE INHIBITION | Centennial Therapeutics, LLC (US) | 2026-04-08 | — | — | EP | claimed |
| EP-4695239-A1 | DISUBSTITUTED PYRIMIDINE COMPOUNDS FOR KETOHEXOKINASE INHIBITION | Centennial Therapeutics, LLC (US) | 2026-02-18 | — | — | EP | claimed |
| EP-3787631-B1 | MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS | UNIV EMORY (US) | 2025-09-10 | — | — | EP | claimed |
| EP-4580674-A2 | ANTIGEN BINDING MOLECULES TARGETING PROGRAMMED CELL DEATH PROTEIN 1 (PD-1) | Flagship Pioneering Innovations VI, LLC (US) | 2025-07-09 | — | — | EP | claimed |
| CN-120189426-A | Application of mizoribine in preparation of preparation for inhibiting influenza virus | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 2025-06-24 | — | — | CN | claimed |
| CN-120131649-A | Application of wocelotor in preparation of preparation for inhibiting influenza virus | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 2025-06-13 | — | — | CN | claimed |
| CN-119971038-A | Compositions and methods for treating galactosylation | 应用治疗公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119970667-A | Epalrestat sustained release tablet and preparation method thereof | 沈阳信达泰康医药科技有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119950522-A | Application of triptolide in preparation of preparation for inhibiting influenza virus | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 2025-05-09 | — | — | CN | claimed |
| CN-119950504-A | Application of epalrestat in preparation of preparation for inhibiting influenza virus | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 2025-05-09 | — | — | CN | claimed |
| CN-1261804-A | Pharmaceutical compositions comprising an aldose reductase inhibitor and an ACE inhibitor | ZENECA LTD (GB) | 2000-08-02 | — | — | CN | claimed |
| WO-2000037066-A2 | A METHOD FOR THE PROPHYLACTIC TREATMENT OF CATARACTS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2000-06-29 | — | — | WO | claimed |
| EP-0991424-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALDOSE REDUCTASE INHIBITOR AND AN ACE INHIBITOR | ZENECA LIMITED (GB) | 2000-04-12 | — | — | EP | claimed |
| EP-0983060-A1 | SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME | IMARX PHARMACEUTICAL CORP. (US) | 2000-03-08 | — | — | EP | claimed |
| WO-1999002189-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALDOSE REDUCTASE INHIBITOR AND AN ACE INHIBITOR | ZENECA LIMITED (GB) | 1999-01-21 | — | — | WO | claimed |
| WO-1998051282-A1 | SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME | IMARX PHARMACEUTICAL CORP. (US) | 1998-11-19 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| WO-1998022114-A1 | A METHOD FOR PROMOTING TISSUE REPAIR | DUMEX-ALPHARMA A/S (DK) | 1998-05-28 | — | — | WO | claimed |
| US-5693337-A | OIL IN WATER EMULSION CONTAINING DRUG, LECITHIN, CITRIC ACID, AND METHIONINE, PHENYLALANINE, SERINE, AND/OR HISTIDINE; SYNERGISTIC, STORAGE STABILITY | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1997-12-02 | — | — | US | claimed |
| EP-0700678-A1 | Stable lipid emulsion | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1996-03-13 | — | — | EP | claimed |