Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Epalrestat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 known ✓ | P15121 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | AKR1A1 | P14550 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Epalrestat SCHEMBL1649205 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL17223887 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL49049 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL49048 | 1.00 | MAPT (1.00) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL27969659 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL27969660 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL29229735 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL28070020 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL1331526 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 | |
| Epalrestat SCHEMBL27969621 | 0.99 | MAPT (0.98) | MAPTLMNANPC1AKR1B1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004210711-A | COATED PREPARATION AND METHOD FOR PRODUCING THE SAME | ONO PHARMACEUT CO LTD | 2004-07-29 | — | — | JP | disclosed |