Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
| ▸ | COASY | Q13057 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908560 | 1.00 | MAPKAPK2 (0.44) | MAPKAPK2NLRP3TEAD4COASYNPC1 | |
| SCHEMBL4915780 | 0.63 | MAPKAPK2 (0.54) | MAPKAPK2NLRP3HTTRAB9ASMN1; SMN2 | |
| SCHEMBL4927735 | 0.63 | MAPKAPK2 (0.54) | MAPKAPK2NLRP3HTTRAB9ASMN1; SMN2 | |
| SCHEMBL4366319 | 0.62 | MAPKAPK2 (1.00) | MAPKAPK2MAPK1CYP2D6 | |
| SCHEMBL1228404 | 0.61 | MAPKAPK2 (0.61) | MAPKAPK2MAPK1CYP2D6KDR | |
| SCHEMBL4598811 | 0.61 | MAPKAPK2 (0.61) | MAPKAPK2MAPK1CYP2D6 | |
| SCHEMBL4596962 | 0.61 | MAPKAPK2 (0.61) | MAPKAPK2MAPK1CYP2D6 | |
| SCHEMBL4928754 | 0.60 | MAPKAPK2 (0.56) | MAPKAPK2MAPK1CYP2D6 | |
| SCHEMBL4916066 | 0.60 | MAPKAPK2 (0.63) | MAPKAPK2NLRP3MAPK1CYP2D6 | |
| SCHEMBL4914736 | 0.59 | MAPKAPK2 (0.70) | MAPKAPK2CXCR2CXCR1MAPK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | claimed |
| US-20080234266-A1 | Squaric Acid Derivatives II | MERCK PATENT GESELLSCHAFT (DE) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234266-A1 | Squaric Acid Derivatives II | CHEK2, CHEK1, SGK3 | MAPKAPK2 346/4885NLRP3 3953/4885TEAD4 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.