Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4927735 | 1.00 | MAPKAPK2 (0.54) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL4926004 | 0.79 | CASR (0.49) | MAPKAPK2ALDH1A1CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL6176448 | 0.73 | LMNA (0.50) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL6176429 | 0.73 | LMNA (0.50) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL2808694 | 0.73 | LMNA (0.50) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL414424 | 0.72 | HIF1A (0.55) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL10305659 | 0.72 | HIF1A (0.55) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL410935 | 0.72 | HIF1A (0.55) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL27992460 | 0.72 | HIF1A (0.55) | MAPKAPK2ADRB1ADRA1AMIFHTR2A | |
| SCHEMBL4366319 | 0.71 | MAPKAPK2 (1.00) | MAPKAPK2CYP3A4CYP2C9PDGFRAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | CHEK1, CHEK2, SIK1 | MAPKAPK2 377/4885ADRB1 4066/4885ADRA1A 3742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.