Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 4/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 2/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13549091 | 0.90 | PREP (0.49) | DPP4DPP8DPP9DPP7TLR2 | |
| SCHEMBL5348559 | 0.87 | DPP4 (0.53) | DPP4DPP8DPP9DPP7TLR2 | |
| SCHEMBL15960070 | 0.85 | PRCP (0.51) | TLR2TLR1ITGB3ITGA2BPRCP | |
| SCHEMBL30640764 | 0.85 | PRCP (0.51) | TLR2TLR1ITGB3ITGA2BPRCP | |
| SCHEMBL29696668 | 0.85 | PRCP (0.51) | TLR2TLR1ITGB3ITGA2BPRCP | |
| SCHEMBL13882551 | 0.84 | DPP4 (0.73) | DPP4DPP8DPP9DPP7KMT2A | |
| SCHEMBL13034950 | 0.83 | DPP4 (0.47) | DPP4DPP8DPP9DPP7TLR2 | |
| SCHEMBL30633846 | 0.83 | CMA1 (0.49) | TLR2TLR1ITGB3ITGA2BPRCP | |
| SCHEMBL13702142 | 0.82 | TLR2 (0.53) | TLR2TLR1ITGB3ITGA2BKMT2A | |
| SCHEMBL13034909 | 0.81 | ITGB3 (0.47) | DPP4DPP8DPP9DPP7ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140371148-A1 | PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF USING SAME | ASTRAZENECA PHARMACEUTICALS LP | 2014-12-18 | — | — | US | disclosed |
| US-20140371148-A1 | PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF USING SAME | ASTRAZENECA PHARMACEUTICALS LP | 2014-12-18 | — | — | US | disclosed |
| US-8759295-B2 | Peptide-peptidase inhibitor conjugates and methods of using same | AMYLIN PHARMACEUTICALS, LLC (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759295-B2 | Peptide-peptidase inhibitor conjugates and methods of using same | AMYLIN PHARMACEUTICALS, LLC (US) | 2014-06-24 | — | — | US | disclosed |
| US-20100292172-A1 | Peptide-Peptidase Inhibitor Conjugates and Methods of Using Same | AMYLIN PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100292172-A1 | Peptide-Peptidase Inhibitor Conjugates and Methods of Using Same | AMYLIN PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100286365-A1 | PEPTIDE-PEPTIDASE-INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME | AMYLIN PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100286365-A1 | PEPTIDE-PEPTIDASE-INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME | AMYLIN PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| US-20090186817-A1 | PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF USING SAME | AMYLIN PHARMACEUTICALS, INC. (US) | 2009-07-23 | — | — | US | disclosed |
| US-20090186817-A1 | PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF USING SAME | AMYLIN PHARMACEUTICALS, INC. (US) | 2009-07-23 | — | — | US | disclosed |
| WO-2009042922-A2 | PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME | AMYLIN PHARMACEUTICALS, INC. (US) | 2009-04-02 | — | — | WO | disclosed |
| US-20080255126-A1 | Inhibitors of post-proline cleaving proteases | FERRING B.V. | 2008-10-16 | — | — | US | disclosed |
| US-7335677-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING B.V. (NL) | 2008-02-26 | — | — | US | disclosed |
| US-7189728-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING, BV (NL) | 2007-03-13 | — | — | US | disclosed |
| US-7125863-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING BV (NL) | 2006-10-24 | — | — | US | disclosed |
| EP-1693365-A1 | Inhibitors of dipeptidyl peptidase IV | FERRING B.V. (NL) | 2006-08-23 | — | — | EP | disclosed |
| US-20050043299-A1 | Inhibitors of dipeptidyl peptidase iv | FERRING B. V. | 2005-02-24 | — | — | US | disclosed |
| EP-1280797-B1 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | FERRING BV (NL) | 2004-10-13 | — | — | EP | disclosed |
| US-20040082497-A1 | Inhibitors of dipeptidyl peptidase IV | FERRING BV (NL) | 2004-04-29 | — | — | US | disclosed |
| US-20030216450-A1 | Inhibitors of dipeptidyl peptidase IV | FERRING BV (NL) | 2003-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216450-A1 | Inhibitors of dipeptidyl peptidase IV | DPP4, DPP7, DPP8 | DPP4 1/4885DPP8 3/4885DPP9 5/4885 |
| US-20100292172-A1 | Peptide-Peptidase Inhibitor Conjugates and Methods of Using Same | DNPEP, PEPD, VIP | DPP4 9/4885DPP8 12/4885DPP9 8/4885 |
| US-20040082497-A1 | Inhibitors of dipeptidyl peptidase IV | DPP4, DPP7, DPP3 | DPP4 1/4885DPP8 6/4885DPP9 4/4885 |
| US-20090186817-A1 | PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF USING SAME | DNPEP, PEPD, VIP | DPP4 9/4885DPP8 12/4885DPP9 8/4885 |
| US-20050043299-A1 | Inhibitors of dipeptidyl peptidase iv | DPP4, DPP9, DPP3 | DPP4 1/4885DPP8 9/4885DPP9 2/4885 |
| US-20080255126-A1 | Inhibitors of post-proline cleaving proteases | PREP, PEPD, DPP4 | DPP4 3/4885DPP8 16/4885DPP9 8/4885 |
| US-20140371148-A1 | PEPTIDE-PEPTIDASE INHIBITOR CONJUGATES AND METHODS OF USING SAME | DNPEP, PEPD, VIP | DPP4 9/4885DPP8 12/4885DPP9 8/4885 |
| US-20100286365-A1 | PEPTIDE-PEPTIDASE-INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME | DNPEP, PEPD, VIP | DPP4 11/4885DPP8 13/4885DPP9 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.