Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905921 | 0.90 | NPC1 (0.47) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4906630 | 0.82 | NPC1 (0.43) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4896735 | 0.82 | NPC1 (0.43) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3349518 | 0.80 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1L3MBTL1TSHR | |
| SCHEMBL4905790 | 0.77 | TDP1 (0.53) | LMNAL3MBTL1KMT2AMEN1 | |
| SCHEMBL4908073 | 0.77 | TSHR (0.51) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4905536 | 0.75 | ALDH1A1 (0.39) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4905521 | 0.75 | ALDH1A1 (0.39) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4906618 | 0.73 | NPC1 (0.43) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4896724 | 0.73 | NPC1 (0.43) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080311609-A1 | Novel Molecular Probes | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080311609-A1 | Novel Molecular Probes | BACE1, BACE2, PSEN1 | NPC1 398/4885RAB9A 3398/4885ALDH1A1 1417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.