Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | LHCGR | P22888 | 5/20 | 0.34 |
| ▸ | BRAF | P15056 | 5/20 | 0.33 |
| ▸ | PDE4A | P27815 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4904105 | 0.81 | BRAF (0.52) | KDM4ERIPK2BRAFPDE4APDE4B | |
| SCHEMBL4911950 | 0.80 | LMNA (0.40) | KDM4ERIPK2BRAFPDE4APDE4B | |
| SCHEMBL4909700 | 0.76 | TEAD2 (0.41) | KDM4ELHCGRTSHRALDH1A1HPGD | |
| SCHEMBL4899220 | 0.68 | BRAF (0.61) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL4904192 | 0.68 | BRAF (0.74) | LHCGRBRAFPDE4APDE4BPDE4C | |
| SCHEMBL4906890 | 0.65 | HSP90AB1 (0.51) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL4903971 | 0.64 | KMT2A (0.53) | KDM4EALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL4906040 | 0.64 | CYP1A2 (0.71) | ALDH1A1HPGDKMT2ALMNAMEN1 | |
| SCHEMBL5461955 | 0.64 | KDM4E (0.43) | KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL4907427 | 0.63 | BRAF (0.55) | KDM4ELHCGRBRAFPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | PDE4A, PDE4B, BRAF | KDM4E 2429/4885RIPK2 2360/4885LHCGR 2693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.