SCHEMBL4906701

SCHEMBL4906701

CCc1nccc(-c2c(-c3ccc(F)cc3)nc3cc(C4CCN(C(=O)OCc5ccccc5)CC4)ccn23)n1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPC3 Q13507 1/20 0.47
TRPC7 Q9HCX4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4835253 0.91 TRPC3 (0.49) TRPC3TRPC7
SCHEMBL4468918 0.90 MAPK14 (0.52)
SCHEMBL4893233 0.89 TRPC3 (0.47) TRPC3TRPC7
SCHEMBL4836747 0.88 TRPC3 (0.47) TRPC3TRPC7
SCHEMBL4838123 0.83
SCHEMBL4470242 0.82 TRPC3 (0.51) TRPC3TRPC7
SCHEMBL4838636 0.77 TRPC3 (0.46) TRPC3TRPC7
SCHEMBL4829651 0.76
SCHEMBL4458503 0.76 TRPC3 (0.53) TRPC3TRPC7
SCHEMBL14064418 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7429590-B2 Antiprotozoal imidazopyridine compounds MERCK & CO. INC. (US) 2008-09-30 US disclosed