Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 4/20 | 0.86 |
| ▸ | JUN | P05412 | 3/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.78 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.78 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.78 |
| ▸ | STAT3 | P40763 | 2/20 | 0.78 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.78 |
| ▸ | RELA | Q04206 | 2/20 | 0.78 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.78 |
| ▸ | APP | P05067 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | CA12 | O43570 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | CA3 | P07451 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | CA4 | P22748 | 2/20 | 0.63 |
| ▸ | CA6 | P23280 | 2/20 | 0.63 |
| ▸ | CA5A | P35218 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906742 | 1.00 | NFKB1 (0.86) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL3207347 | 0.93 | NFKB1 (1.00) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL3207352 | 0.93 | NFKB1 (1.00) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL18270515 | 0.92 | NFKB1 (0.71) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL19534824 | 0.91 | GSK3B (0.72) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL2744234 | 0.90 | CYP2D6 (0.91) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL2744233 | 0.90 | CYP2D6 (0.91) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL2173807 | 0.90 | APP (0.80) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL29478095 | 0.89 | CYP2D6 (1.00) | NFKB1JUNCYP2D6CYP1A2ALOX5 | |
| SCHEMBL1493283 | 0.89 | CYP2D6 (1.00) | NFKB1JUNCYP2D6CYP1A2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432401-B2 | Method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties | Fundação de Amparo a Pesquisa Do Estado de São Paulo (BR) | 2008-10-07 | — | — | US | disclosed |
| US-20060128997-A1 | New method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties | FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO (BR) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128997-A1 | New method for the preparation of 1,5-bis(4-hydroxy-3-metoxy-phenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties | DDB1, ANXA1, ANXA5 | NFKB1 310/4885JUN 3433/4885CYP2D6 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.