Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | VEGFA | P15692 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4244349 | 0.89 | ALDH1A1 (0.45) | ALDH1A1CYP3A4HPGDTDP1SMN1; SMN2 | |
| SCHEMBL13556579 | 0.78 | CYP3A4 (0.51) | ALDH1A1CYP3A4HPGDTDP1EPAS1 | |
| SCHEMBL1943486 | 0.73 | CYP3A4 (0.69) | ALDH1A1CYP3A4HPGDTDP1SMN1; SMN2 | |
| SCHEMBL14992 | 0.73 | CYP3A4 (1.00) | ALDH1A1CYP3A4HPGDTDP1TSHR | |
| SCHEMBL29350162 | 0.73 | CYP3A4 (1.00) | ALDH1A1CYP3A4HPGDTDP1TSHR | |
| SCHEMBL13483626 | 0.72 | EPAS1 (0.57) | ALDH1A1SMN1; SMN2POLBTSHRMAPK1 | |
| SCHEMBL5252562 | 0.72 | ALDH1A1 (0.71) | ALDH1A1CYP3A4HPGDTDP1SMN1; SMN2 | |
| SCHEMBL543088 | 0.72 | CYP3A4 (0.71) | ALDH1A1CYP3A4HPGDTDP1TSHR | |
| SCHEMBL29541267 | 0.72 | ALDH1A1 (0.71) | ALDH1A1CYP3A4HPGDTDP1SMN1; SMN2 | |
| SCHEMBL29800238 | 0.72 | CYP3A4 (0.71) | ALDH1A1CYP3A4HPGDTDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | MILLER SCOTT | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | BRAF, RAF1, MAP2K2 | ALDH1A1 2032/4885CYP3A4 3074/4885HPGD 3567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.