Sugi Predict

Sugi Predict / Compounds / SCHEMBL4907494

SCHEMBL4907494

SCHEMBL4907494

Cc1cc(S(=O)(=O)NCCc2nc(-c3ccc(C(C)(C)C)cc3)sc2C)cc(C(=O)O)c1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 6/20 0.40
▸ ALDH1A1 P00352 4/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ HTT P42858 2/20 0.40
▸ MAPT P10636 6/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ TP53 P04637 4/20 0.37
▸ THRB P10828 1/20 0.37
▸ NR1H4 Q96RI1 1/20 0.37
▸ HDAC3 O15379 1/20 0.37
▸ HDAC1 Q13547 1/20 0.37
▸ HDAC2 Q92769 1/20 0.37
▸ HDAC8 Q9BY41 1/20 0.37
▸ HDAC6 Q9UBN7 1/20 0.37
▸ PPARG P37231 1/20 0.35
▸ PPARD Q03181 1/20 0.35
▸ PPARA Q07869 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4895286 0.92 MAPT (0.42) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4895165 0.91 LMNA (0.40) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4903641 0.91 MAPT (0.42) LMNAALDH1A1MAPTMEN1KMT2A
SCHEMBL4907182 0.90 LMNA (0.46) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4903797 0.90 LMNA (0.46) LMNAALDH1A1HTTMAPTTP53
SCHEMBL4904358 0.89 MAPT (0.44) LMNASMN1; SMN2MAPTKDM4ETP53
SCHEMBL4906613 0.89 MAPT (0.44) LMNAMAPTTP53THRBPPARG
SCHEMBL4906209 0.87 PPARA (0.48) LMNAMAPTTP53PPARGPPARD
SCHEMBL4906394 0.87 LMNA (0.41) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4903767 0.86 LMNA (0.40) LMNAALDH1A1MAPTTP53THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885ALDH1A1 2664/4885SMN1; SMN2 3271/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885SMN1; SMN2 3404/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885SMN1; SMN2 3404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.