Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.58 |
| ▸ | NPC1 | O15118 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ILK | Q13418 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 3/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21779833 | 0.83 | KDM4E (0.63) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL21301181 | 0.83 | KDM4E (0.58) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL900512 | 0.83 | KDM4E (0.58) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL11489855 | 0.83 | KDM4E (0.58) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL21699657 | 0.83 | KDM4E (0.58) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL24182079 | 0.83 | KDM4E (0.63) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL231307 | 0.82 | KDM4E (0.75) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL21362250 | 0.81 | KDM4E (0.59) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL8045063 | 0.81 | KDM4E (0.55) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL12854008 | 0.80 | KDM4E (0.72) | KDM4ENPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080299041-A1 | HETEROCYCLIC INDENE DERIVATIVES AND THEIR RADIOISOTOPE LABELED COMPOUNDS FOR IMAGING BETA-AMYLOID DEPOSITION | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080299041-A1 | HETEROCYCLIC INDENE DERIVATIVES AND THEIR RADIOISOTOPE LABELED COMPOUNDS FOR IMAGING BETA-AMYLOID DEPOSITION | APP, BACE1, PSEN1 | KDM4E 3533/4885NPC1 41/4885RAB9A 2635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.