Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863265 | 0.95 | MAPK14 (0.54) | MAPK14HSD17B1HSD17B2HTTKMT2A | |
| SCHEMBL2894252 | 0.85 | MAPK14 (0.55) | MAPK14HSD17B1HSD17B2HTTKMT2A | |
| SCHEMBL665128 | 0.80 | HSD17B2 (0.66) | MAPK14HSD17B1HSD17B2KDM4ECLK1 | |
| SCHEMBL12574227 | 0.78 | MAPK14 (0.46) | MAPK14HTTKMT2AMEN1KCNN4 | |
| SCHEMBL18816698 | 0.77 | HSD17B10 (0.54) | MAPK14HTTKMT2AKDM4EMEN1 | |
| SCHEMBL29273240 | 0.75 | KMT2A (0.62) | HTTKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL17265581 | 0.73 | MAPK14 (0.45) | MAPK14KMT2AMEN1KCNN4KCNA5 | |
| SCHEMBL9567794 | 0.73 | KMT2A (0.68) | HTTKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL9001629 | 0.73 | KMT2A (0.62) | HSD17B1HSD17B2HTTKMT2AKDM4E | |
| SCHEMBL4181087 | 0.72 | KMT2A (0.57) | HSD17B1HSD17B2HTTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384963-B2 | 2′-Methyl-5-(1,3,4-oxadiazol-2-yl)1, 1′-biphenyl-4-carboxaide derivatives and their use as p38 kinase | GLAXO GROUP LIMITED (GB) | 2008-06-10 | — | — | US | disclosed |