Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.69 |
| ▸ | HTR2C | P28335 | 7/20 | 0.69 |
| ▸ | HTR2B | P41595 | 7/20 | 0.69 |
| ▸ | HTR1A | P08908 | 5/20 | 0.69 |
| ▸ | DRD3 | P35462 | 5/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.69 |
| ▸ | DRD1 | P21728 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | HTR7 | P34969 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.69 |
| ▸ | HRH1 | P35367 | 2/20 | 0.69 |
| ▸ | HTR3A | P46098 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911654 | 1.00 | HTR2A (0.69) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Mirtazapine SCHEMBL966891 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Esmirtazapine SCHEMBL29579803 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Mirtazapine SCHEMBL35408 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Mirtazapine SCHEMBL8271559 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Mirtazapine SCHEMBL29484433 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Mirtazapine SCHEMBL29579914 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Esmirtazapine SCHEMBL49330 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Mirtazapine SCHEMBL2483266 | 0.81 | HTR2A (0.97) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| Mirtazapine SCHEMBL355514 | 0.81 | HTR2A (0.97) | HTR2AHTR2CHTR2BHTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146993-B1 | A METHOD FOR THE PREPARATION OF MIRTAZAPINE | MERCK SHARP & DOHME (NL) | 2015-08-05 | — | — | EP | disclosed |
| EP-2146993-B1 | A METHOD FOR THE PREPARATION OF MIRTAZAPINE | MERCK SHARP & DOHME (NL) | 2015-08-05 | — | — | EP | disclosed |
| WO-2008125578-A2 | A METHOD FOR THE PREPARATION OF MIRTAZAPINE | N.V. ORGANON (NL) | 2008-10-23 | — | — | WO | disclosed |
| US-20080255348-A1 | METHOD FOR THE PREPARATION OF AN ENANTIOMER OF A TETRACYCLIC BENZAZEPINE | N.V. ORGANON | 2008-10-16 | — | — | US | disclosed |
| US-20080255348-A1 | METHOD FOR THE PREPARATION OF AN ENANTIOMER OF A TETRACYCLIC BENZAZEPINE | N.V. ORGANON | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255348-A1 | METHOD FOR THE PREPARATION OF AN ENANTIOMER OF A TETRACYCLIC BENZAZEPINE | CYP3A5, HMGCR, CYP11A1 | HTR2A 150/4885HTR2C 96/4885HTR2B 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.