SCHEMBL4908401

SCHEMBL4908401

O=C(/C=C/c1ccccc1Cl)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.78
KMT2A Q03164 3/20 0.78
MEN1 O00255 2/20 0.78
HSP90AA1 P07900 1/20 0.78
MAOB P27338 6/20 0.69
LMNA P02545 4/20 0.69
ALDH1A1 P00352 1/20 0.69
HPGD P15428 1/20 0.69
ABCG2 Q9UNQ0 2/20 0.60
CYP1B1 Q16678 3/20 0.59
CYP1A1 P04798 1/20 0.59
CYP1A2 P05177 1/20 0.59
CYP2D6 P10635 1/20 0.59
AHR P35869 1/20 0.59
HDAC1 Q13547 1/20 0.59
HDAC8 Q9BY41 1/20 0.59
HDAC6 Q9UBN7 1/20 0.59
GSR P00390 1/20 0.59
NPC1 O15118 2/20 0.58
RAB9A P51151 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30477506 1.00 MAPT (0.78) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL4908405 1.00 MAPT (0.78) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL11318820 1.00 MAPT (0.78) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL11480487 0.91 MAPT (0.77) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL11480491 0.91 MAPT (0.77) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL10416123 0.89 MAPT (0.79) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL9779305 0.88 PTGS2 (0.69) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL9779303 0.88 PTGS2 (0.69) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL28706431 0.88 MAPT (1.00) MAPTKMT2AMEN1HSP90AA1MAOB
SCHEMBL21647112 0.86 MAPT (0.65) MAPTKMT2AMEN1HSP90AA1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8759112-B2 Multifunctional reference system for analyte determinations by fluorescence ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2014-06-24 US claimed
US-20080014655-A1 Multifunctional Reference System For Analyte Determinations By Fluorescence ROCHE DIAGNOSTICS OPERATIONS, INC. (IN) 2008-01-17 US claimed
CN-114456086-B Synthesis method of beta-cyano ketone 哈尔滨理工大学 2024-10-01 CN disclosed
CN-114456086-A Synthesis method of beta-cyano ketone 哈尔滨理工大学 2022-05-10 CN disclosed
CN-104030984-B A kind of preparation method of pyrazole derivatives 甘肃农业大学 2016-07-13 CN disclosed
US-8759112-B2 Multifunctional reference system for analyte determinations by fluorescence ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2014-06-24 US disclosed
CN-101450300-A Continuous current micro-reactor and preparation method and use thereof UNIV HAINAN (CN) 2009-06-10 CN disclosed
US-20080014655-A1 Multifunctional Reference System For Analyte Determinations By Fluorescence ROCHE DIAGNOSTICS OPERATIONS, INC. (IN) 2008-01-17 US disclosed
US-5492915-A ANTIINFLAMMATORY AGENTS RHONE-POULENC RORER S.A. (FR) 1996-02-20 US disclosed
US-5366982-A Antiinflammatory agents or antihistamines RHONE-POULENC RORER S.A. (FR) 1994-11-22 US disclosed
US-5037824-A Cardiotonic, antiischemic agents FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1991-08-06 US disclosed
EP-0387070-A2 N-Containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-09-12 EP disclosed
US-4367280-A AROMATIC CARBONYL COMPOUND AND P-DIALKYLAMINO AROMATIC CARBONYL COMPOUND COMBINATION POLYMERIZATION INITIATOR FUJI PHOTO FILM CO., LTD. (JP) 1983-01-04 US disclosed
US-4058532-A 1-Phenyl-3,4-dihydrocarbostyrils STERLING DRUG INC. (US) 1977-11-15 US disclosed
US-4049715-A 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols STERLING DRUG INC. (US) 1977-09-20 US disclosed
US-3994902-A Certain 1,2-diphenyl-1,2,3,4-tetrahydroquinoline compounds STERLING DRUG INC. (US) 1976-11-30 US disclosed