Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906700 | 0.91 | KDM4E (0.43) | MAPK14MAPK11KDM4EEGLN1MEN1 | |
| SCHEMBL4591225 | 0.87 | KDM5A (0.34) | TP53GRIN1GRIN2BMAPTTHRB | |
| SCHEMBL14067487 | 0.85 | MEN1 (0.39) | KDM4EMAPTEGLN1MEN1KMT2A | |
| SCHEMBL4591311 | 0.83 | KDM4E (0.42) | MAPK14MAPK11KDM4EMEN1KMT2A | |
| SCHEMBL4906293 | 0.82 | KDM4E (0.48) | MAPK14MAPK11KDM4EMEN1KMT2A | |
| SCHEMBL4591057 | 0.81 | KDM4E (0.42) | MAPK14MAPK11KDM4EMEN1KMT2A | |
| SCHEMBL4906366 | 0.80 | KDM4E (0.44) | MAPK14MAPK11KDM4EMEN1KMT2A | |
| SCHEMBL4908796 | 0.80 | MEN1 (0.42) | KDM4EGRIN1GRIN2BEGLN1MEN1 | |
| SCHEMBL4901060 | 0.80 | KDM4E (0.43) | MAPK14MAPK11KDM4EMEN1KMT2A | |
| SCHEMBL4591622 | 0.80 | HIF1A (0.34) | MAPTEGLN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214527-A1 | Hiv Integrase Inhibitors | SHIONOGI & CO. LTD (JP) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214527-A1 | Hiv Integrase Inhibitors | API5, ING2, SAMHD1 | MAPK14 2377/4885MAPK11 2598/4885KDM4E 1139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.