Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.72 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.72 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.72 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.72 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.72 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584767 | 1.00 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL4908878 | 1.00 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL6584774 | 1.00 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| Hydrochloric Acid SCHEMBL6583319 | 0.99 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| Hydrochloric Acid SCHEMBL8851513 | 0.99 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| Hydrochloric Acid SCHEMBL6583323 | 0.99 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| Hydrochloric Acid SCHEMBL8851521 | 0.99 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| Hydrochloric Acid SCHEMBL7691195 | 0.99 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| Hydrochloric Acid SCHEMBL6586090 | 0.99 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL6583359 | 0.84 | CHRNB2 (1.00) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | claimed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | claimed |
| US-10098970-B2 | Compostions and methods for diagnosis of axial pain with or without radiculopathy | WARSAW ORTHOPEDIC, INC. (US) | 2018-10-16 | — | — | US | disclosed |
| US-9757476-B2 | Compositions and methods for diagnosis of axial pain with or without radiculopathy | WARSAW ORTHOPEDIC, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20170216459-A1 | COMPOSTIONS AND METHODS FOR DIAGNOSIS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY | WARSAW ORTHOPEDIC INC (US) | 2017-08-03 | — | — | US | disclosed |
| US-8333697-B2 | Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy | WARSAW ORTHOPEDIC, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| US-20080008988-A1 | Compositions and methods for diagnosis of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2008-01-10 | — | — | US | disclosed |
| US-20070298407-A1 | Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-27 | — | — | US | disclosed |
| US-20070287991-A1 | Devices and methods for detection of markers of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-13 | — | — | US | disclosed |
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| US-5629325-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1997-05-13 | — | — | US | disclosed |