Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.59 |
| ▸ | FBP1 | P09467 | 6/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 2/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3441078 | 0.84 | MEN1 (0.46) | ADORA2AADORA1ADORA3ADORA2BMEN1 | |
| SCHEMBL4372078 | 0.82 | ADORA2A (0.49) | ADORA2AADORA1ADORA3ADORA2BFBP1 | |
| SCHEMBL17897916 | 0.76 | HSP90B1 (0.67) | FBP1HSP90AA1HSP90AB1 | |
| SCHEMBL27774799 | 0.72 | PI4KA (0.56) | ADORA2AADORA1ADORA3ADORA2BFBP1 | |
| SCHEMBL5358021 | 0.71 | ADORA2A (0.69) | ADORA2AADORA1ADORA3ADORA2BFBP1 | |
| SCHEMBL5357844 | 0.71 | ADORA2A (0.73) | ADORA2AADORA1ADORA3ADORA2BFBP1 | |
| SCHEMBL5447019 | 0.71 | FBP1 (0.65) | ADORA2AADORA1ADORA3ADORA2BFBP1 | |
| SCHEMBL1914306 | 0.69 | ADORA2A (0.71) | ADORA2AADORA1ADORA3ADORA2BFBP1 | |
| SCHEMBL5731775 | 0.69 | ADORA2A (0.71) | ADORA2AADORA1ADORA3ADORA2BFBP1 | |
| SCHEMBL4341941 | 0.69 | ADORA2A (1.00) | ADORA2AADORA1ADORA3ADORA2BFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230123747-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2023-04-20 | — | — | US | disclosed |
| CN-105899503-B | Selective GRP94 inhibitors and uses thereof | 纪念斯隆-凯特琳癌症中心 | 2020-08-18 | — | — | CN | disclosed |
| US-20200102312-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2020-04-02 | — | — | US | disclosed |
| US-10421758-B2 | Selective Grp94 inhibitors and uses thereof | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2019-09-24 | — | — | US | disclosed |
| US-20160194328-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2016-07-07 | — | — | US | disclosed |
| EP-3033338-A2 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | Memorial Sloan-Kettering Cancer Center (US) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015023976-A2 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2015-02-19 | — | — | WO | disclosed |
| US-8703942-B2 | Small-molecule Hsp90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-04-22 | — | — | US | disclosed |
| US-7439359-B2 | Small molecule compositions for binding to hsp90 | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2008-10-21 | — | — | US | disclosed |
| EP-1335920-A4 | SMALL MOLECULE COMPOSITIONS FOR BINDING TO HSP90 | SLOAN KETTERING INSTITUTEFOR C (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20040102458-A1 | Small molecule compositions for binding to hsp90 | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2004-05-27 | — | — | US | disclosed |
| EP-1335920-A2 | SMALL MOLECULE COMPOSITIONS FOR BINDING TO HSP90 | Sloan-Kettering Institute For Cancer Research (US) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002036075-A2 | SMALL MOLECULE COMPOSITIONS FOR BINDING TO HSP90 | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194328-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | HSP90B1, HSP90AB2P, HSPE1 | ADORA2A 3584/4885ADORA1 3920/4885ADORA3 3800/4885 |
| US-10421758-B2 | Selective Grp94 inhibitors and uses thereof | HSP90B1, HSP90AB2P, HSPE1 | ADORA2A 3584/4885ADORA1 3920/4885ADORA3 3800/4885 |
| US-20040102458-A1 | Small molecule compositions for binding to hsp90 | HSP90AB1, ERBB2, HSP90AB2P | ADORA2A 1516/4885ADORA1 1947/4885ADORA3 2104/4885 |
| US-20200102312-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | HSP90B1, HSP90AB2P, HSPE1 | ADORA2A 3584/4885ADORA1 3920/4885ADORA3 3800/4885 |
| US-20230123747-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | HSP90B1, HSP90AB2P, HSPE1 | ADORA2A 3584/4885ADORA1 3920/4885ADORA3 3800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.