Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.56 |
| ▸ | PDE4A | P27815 | 5/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.55 |
| ▸ | LHCGR | P22888 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907114 | 0.90 | BRAF (0.67) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4900820 | 0.87 | LHCGR (0.51) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4908318 | 0.85 | BRAF (0.57) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907672 | 0.85 | BRAF (0.49) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4908826 | 0.81 | BRAF (0.57) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281425 | 0.81 | BRAF (0.85) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4430436 | 0.78 | LHCGR (0.77) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4909310 | 0.77 | BRAF (0.71) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4909271 | 0.77 | BRAF (0.47) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907251 | 0.77 | LHCGR (0.57) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | PDE4A, PDE4B, BRAF | BRAF 3/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.