Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.64 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.64 |
| ▸ | KDM1A | O60341 | 12/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | RAD52 | P43351 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10313317 | 0.92 | KDM1A (0.72) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL18407164 | 0.89 | TOP2A (0.73) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL8111716 | 0.82 | TOP2A (0.64) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL9299406 | 0.82 | TOP2A (0.68) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL7563689 | 0.80 | TOP2A (0.77) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL17154397 | 0.80 | KDM1A (0.68) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL14116115 | 0.80 | KDM1A (0.68) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL7564567 | 0.79 | TOP2A (0.82) | TOP2ATOP2BKDM1AKMT2AMEN1 | |
| SCHEMBL29536689 | 0.78 | TOP2A (1.00) | TOP2ATOP2BKDM1APOLBRAD52 | |
| SCHEMBL1865418 | 0.78 | TOP2A (1.00) | TOP2ATOP2BKDM1APOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193687-B2 | Phenyl N-mustard linked to DNA-affinic molecules or water-soluble aryl rings, method and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2015-11-24 | — | — | US | disclosed |
| US-9193687-B2 | Phenyl N-mustard linked to DNA-affinic molecules or water-soluble aryl rings, method and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2015-11-24 | — | — | US | disclosed |
| US-20130178494-A1 | PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS | ACADEMIA SINICA (TW) | 2013-07-11 | — | — | US | disclosed |
| US-8222297-B2 | e.g. 1-[3-(acridin-9-ylamino)-5-hydroxymethylphenyl]-3-{4-[bis(2-chloroethyl)amino]phenyl}urea; anticarcinogenic agent; improved chemical stability and efficacy; brain tumor, breast cancer, colon cancer, leukemia, and neuroblastoma | ACADEMIA SINICA (TW) | 2012-07-17 | — | — | US | disclosed |
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2008-07-17 | — | — | US | disclosed |
| US-6821983-B2 | INHIBITORS OF TOPOISOMERASE II CAN EXHIBIT ANTITUMOR ACTIVITY | ACADEMIA SINICA (TW) | 2004-11-23 | — | — | US | disclosed |
| US-20040198765-A1 | 5-(9-ACRIDINYLAMINO)-TOLUIDINE COMPOUNDS | ACADEMIA SINICA (TW) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | WEE1, PCNA, ATIC | TOP2A 16/4885TOP2B 19/4885KDM1A 722/4885 |
| US-20130178494-A1 | PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS | PCNA, WEE1, UNG | TOP2A 6/4885TOP2B 15/4885KDM1A 995/4885 |
| US-20040198765-A1 | 5-(9-ACRIDINYLAMINO)-TOLUIDINE COMPOUNDS | DPP9, NANP, NAT1 | TOP2A 3007/4885TOP2B 3144/4885KDM1A 3382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.