Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747905 | 0.75 | ALDH1A1 (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| Biphenyl SCHEMBL8502577 | 0.68 | ALDH1A1 (0.82) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| Biphenyl SCHEMBL27573866 | 0.68 | ALDH1A1 (0.82) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL216526 | 0.68 | ALDH1A1 (0.67) | ALDH1A1RAB9ANPC1MAPK1TAAR1 | |
| Biphenyl SCHEMBL27813018 | 0.67 | ALDH1A1 (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL30108088 | 0.67 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| Biphenyl SCHEMBL4002609 | 0.67 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| Biphenyl SCHEMBL28890607 | 0.67 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| Biphenyl SCHEMBL164 | 0.67 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 | |
| Biphenyl SCHEMBL1358618 | 0.67 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110191639-A | Substituted sulfonamides for combating animal pests | 拜耳公司 | 2019-08-30 | — | — | CN | claimed |
| US-20080161312-A1 | Derivatives of Pyrrolo-Pyrazines Having a Kinase Inhibitory Activity and Their Biological Applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2008-07-03 | — | — | US | claimed |
| EP-1527077-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2005-05-04 | — | — | EP | claimed |
| WO-2004016614-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2004-02-26 | — | — | WO | claimed |
| EP-1388541-A1 | Pyrrolopyrazines as kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2004-02-11 | — | — | EP | claimed |
| WO-2023237097-A1 | 19-NOR-C3,3-DISUBSTITUTED C21-AZACYCLO-SUBSTITUTED STEROID AND METHOD FOR USING SAME | 山东绿叶制药有限公司 | 2023-12-14 | — | — | WO | disclosed |
| CN-113994970-B | Substituted sulfonamides for combating animal pests | 拜耳公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-110191639-A | Substituted sulfonamides for combating animal pests | 拜耳公司 | 2019-08-30 | — | — | CN | disclosed |
| US-8106050-B2 | 6-[1-(4-Chlorophenyl)-1-cyclopropyl][5H]pyrrolo[2,3-b]pyrazine; cyclin-dependent kinases and glycogen synthase kinase-3 inhibitor; antiproliferative, anticarcinogenic agent; neurodegenerative disorders; controlling the cell cycle apoptosis, neuronal functions, transcription and exocytosis | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2012-01-31 | — | — | US | disclosed |
| EP-1807084-B1 | USE OF PYRROLOPYRAZINE DERIVATIVES FOR THE PRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF MUCOVISCIDOSIS | CENTRE NAT RECH SCIENT (FR) | 2010-12-15 | — | — | EP | disclosed |
| US-20090048260-A1 | Use of pyrrolopyrazine derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells | UNIVERSITE DE POITIERS (FR) | 2009-02-19 | — | — | US | disclosed |
| US-20080161312-A1 | Derivatives of Pyrrolo-Pyrazines Having a Kinase Inhibitory Activity and Their Biological Applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2008-07-03 | — | — | US | disclosed |
| EP-1807084-A2 | USE OF PYRROLOPYRAZINE DERIVATIVES FOR THE PRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF MUCOVISCIDOSIS AND DISEASES RELATED TO PROTEIN ADDRESSING ERRORS IN CELLS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006042950-A2 | USE OF PYRROLOPYRAZINE DERIVATIVES FOR THE PRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF MUCOVISCIDOSIS AND DISEASES RELATED TO PROTEIN ADDRESSING ERRORS IN CELLS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2006-04-27 | — | — | WO | disclosed |
| EP-1527077-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004016614-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2004-02-26 | — | — | WO | disclosed |
| EP-1388541-A1 | Pyrrolopyrazines as kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2004-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161312-A1 | Derivatives of Pyrrolo-Pyrazines Having a Kinase Inhibitory Activity and Their Biological Applications | CDK2, PLK2, CDK5 | ALDH1A1 1812/4885RAB9A 2889/4885NPC1 2937/4885 |
| US-20090048260-A1 | Use of pyrrolopyrazine derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells | HRH2, HRH1, HRH4 | ALDH1A1 1645/4885RAB9A 3436/4885NPC1 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.