Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.68 |
| ▸ | KIT | P10721 | 11/20 | 0.55 |
| ▸ | FLT3 | P36888 | 11/20 | 0.55 |
| ▸ | CSF1R | P07333 | 6/20 | 0.49 |
| ▸ | FLT1 | P17948 | 6/20 | 0.49 |
| ▸ | FYN | P06241 | 5/20 | 0.49 |
| ▸ | LYN | P07948 | 5/20 | 0.49 |
| ▸ | FLT4 | P35916 | 5/20 | 0.49 |
| ▸ | BLK | P51451 | 5/20 | 0.49 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2236648 | 0.85 | KDR (0.72) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL1702780 | 0.84 | KDR (0.77) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2237225 | 0.83 | KDR (0.71) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL1703065 | 0.81 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2237945 | 0.79 | KDR (0.75) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL1702788 | 0.78 | KDR (0.76) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2241743 | 0.78 | KDR (0.76) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2238490 | 0.77 | KDR (0.84) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL4912534 | 0.77 | KDR (0.44) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL2237650 | 0.77 | KDR (0.62) | KDRKITFLT3CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2008-02-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | DPYD, TYMP, PCK2 | KDR 2947/4885KIT 358/4885FLT3 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.