Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.55 |
| ▸ | JAK1 | P23458 | 3/20 | 0.55 |
| ▸ | TYK2 | P29597 | 3/20 | 0.55 |
| ▸ | JAK3 | P52333 | 3/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4913069 | 0.93 | JAK2 (0.55) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4911679 | 0.84 | TDP1 (0.62) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL3087113 | 0.83 | TDP1 (0.64) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL10083819 | 0.82 | TDP1 (0.58) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4906853 | 0.81 | TDP1 (0.51) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4913737 | 0.81 | TDP1 (0.55) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13075718 | 0.79 | TDP1 (0.59) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4910308 | 0.79 | TDP1 (0.50) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL5875889 | 0.79 | JAK2 (0.53) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL5875739 | 0.79 | JAK2 (0.57) | TDP1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-6992089-B2 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE UNIVERSITY OF NEW JERSEY (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | TDP1 6/4885JAK2 2554/4885JAK1 2453/4885 |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | TDP1 4/4885JAK2 2690/4885JAK1 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.