Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.46 |
| ▸ | KDM1A | O60341 | 6/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4938439 | 0.93 | TOP2A (0.41) | TOP2ATOP2BKDM1AEGFRERBB2 | |
| SCHEMBL4913194 | 0.92 | TOP2A (0.41) | TOP2ATOP2BKDM1AKDRKDM4E | |
| SCHEMBL4937115 | 0.92 | TOP2A (0.38) | TOP2ATOP2BKDM1AEGFRERBB2 | |
| SCHEMBL4901467 | 0.91 | TOP2A (0.49) | TOP2ATOP2BKDM1AKDRKDM4E | |
| SCHEMBL4905091 | 0.91 | TOP2A (0.49) | TOP2ATOP2BKDM1AALDH1A1MAPT | |
| SCHEMBL4910017 | 0.90 | TOP2A (0.49) | TOP2ATOP2BKDM1AKDR | |
| SCHEMBL4910521 | 0.90 | TOP2A (0.37) | TOP2ATOP2BKDM1AEGFRERBB2 | |
| SCHEMBL4909275 | 0.89 | TOP2A (0.55) | TOP2ATOP2BKDM1AKDM4EMEN1 | |
| SCHEMBL4912328 | 0.89 | KDM1A (0.48) | TOP2ATOP2BKDM1A | |
| SCHEMBL4910224 | 0.87 | EGFR (0.42) | TOP2ATOP2BKDM1AEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222297-B2 | e.g. 1-[3-(acridin-9-ylamino)-5-hydroxymethylphenyl]-3-{4-[bis(2-chloroethyl)amino]phenyl}urea; anticarcinogenic agent; improved chemical stability and efficacy; brain tumor, breast cancer, colon cancer, leukemia, and neuroblastoma | ACADEMIA SINICA (TW) | 2012-07-17 | — | — | US | disclosed |
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | WEE1, PCNA, ATIC | TOP2A 16/4885TOP2B 19/4885KDM1A 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.