SCHEMBL4911049

SCHEMBL4911049

CC(C)CC(O[SiH2]CCCOCC1CO1)C(C)C

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
ALDH1A1 P00352 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL830652 0.82 TSHR (0.55) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL28627231 0.78 SMN1; SMN2 (0.53) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL8442252 0.78 TSHR (0.58) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL28617432 0.77 SMN1; SMN2 (0.56) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL6051332 0.77 SMN1; SMN2 (0.54) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL31426913 0.77 TSHR (0.52) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL29182497 0.76 TSHR (0.55) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL28262740 0.76 TSHR (0.47) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1
SCHEMBL703623 0.75 ANPEP (0.31)
SCHEMBL282265 0.74 SMN1; SMN2 (0.51) TSHRSMN1; SMN2ALDH1A1TDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1922207-A1 INFLATABLE MEMBRANE PRESSING APPARATUS FOR A FILM OR COATING APPLICATION OR LAMINATION PROCESS ESSILOR INTERNATIONAL (Compagnie Générale d'Optique) (FR) 2008-05-21 EP disclosed
US-20080006368-A9 Process for applying a coating onto a surface of a lens substrate ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2008-01-10 US disclosed
WO-2007020236-A1 INFLATABLE MEMBRANE PRESSING APPARATUS FOR A FILM OR COATING APPLICATION OR LAMINATION PROCESS ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) 2007-02-22 WO disclosed
US-20060169407-A1 Process for applying a coating onto a surface of a lens substrate JIANG PEIQI 2006-08-03 US disclosed
US-6986857-B2 Method for preparing a mold part useful for transferring a coating onto an optical substrate ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2006-01-17 US disclosed
US-6890458-B2 Method for forming on-site a coated optical article ESSILOR INTERNATIONAL COMPAGNIE GENERAL D'OPTIQUE (FR) 2005-05-10 US disclosed
US-6887402-B2 Method for transferring from a mold a hydrophobic top coat onto an optical substrate ESSILOR INTERNATIONAL COMPAGNIE GENERAL D'OPTIQUE (FR) 2005-05-03 US disclosed
US-20040065968-A1 Method for preparing a mold part useful for transferring a coating onto an optical substrate ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE 2004-04-08 US disclosed
EP-1401634-A1 METHOD FOR TRANSFERRING FROM A MOLD A HYDROPHOBIC TOP COAT ONTO AN OPTICAL SUBSTRATE ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2004-03-31 EP disclosed
EP-1395417-A2 METHOD FOR FORMING ON-SITE A COATED OPTICAL ARTICLE ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2004-03-10 EP disclosed
US-20030122269-A1 Method for forming on-site a coated optical article ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2003-07-03 US disclosed
US-20030116872-A1 Method for transferring from a mold a hydrophobic top coat onto an optical substrate ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2003-06-26 US disclosed
WO-2002096628-A2 METHOD FOR FORMING ON-SITE A COATED OPTICAL ARTICLE ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2002-12-05 WO disclosed
WO-2002096627-A1 METHOD FOR TRANSFERRING FROM A MOLD A HYDROPHOBIC TOP COAT ONTO AN OPTICAL SUBSTRATE. ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2002-12-05 WO disclosed
US-6315865-B1 Silyl-linked polyamidoamine and their preparation HERCULES INCORPORATED 2001-11-13 US disclosed