Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193576 | 1.00 | KMT2A (0.50) | KMT2ACA12CA9DAOMCL1 | |
| Dimethylamine SCHEMBL11499079 | 0.94 | KMT2A (0.46) | KMT2ACA12CA9DAOMCL1 | |
| SCHEMBL721141 | 0.80 | KMT2A (0.47) | KMT2ACA12CA9DAOMCL1 | |
| SCHEMBL26049788 | 0.79 | KMT2A (0.46) | KMT2ACA12CA9DAOMCL1 | |
| SCHEMBL28298483 | 0.78 | KMT2A (0.42) | KMT2ADAOMCL1ALDH1A1MAPT | |
| SCHEMBL6472453 | 0.78 | SMN1; SMN2 (0.45) | KMT2ACA12CA9DAOMCL1 | |
| SCHEMBL13665375 | 0.77 | DAO (0.46) | KMT2ACA12CA9DAOMCL1 | |
| SCHEMBL17321511 | 0.77 | DAO (0.46) | KMT2ACA12CA9DAOMCL1 | |
| SCHEMBL20436870 | 0.77 | DAO (0.46) | KMT2ACA12CA9DAOMCL1 | |
| SCHEMBL4198025 | 0.76 | MCL1 (0.57) | KMT2ACA12CA9DAOMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928121-A | The high efficiency preparation method of 3- substitution-benzo five-membered heterocycle -2- carbonyls | 暨南大学 | 2017-07-07 | — | — | CN | disclosed |
| US-20110124674-A1 | 5/5-OR 5/6-MEMBERED CONDENSED RING CYCLOALKYLAMINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| CN-101321726-A | Novel fused pyrrole derivative | DAINIPPON SUMITOMO PHARMA CO (JP) | 2008-12-10 | — | — | CN | disclosed |
| US-20080262035-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | MERCK & CO., INC. | 2008-10-23 | — | — | US | disclosed |
| EP-1768956-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006005955-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-01-19 | — | — | WO | disclosed |
| CN-1182086-A | New bisimide compounds, process for preparing them and pharmaceutical compositions containing them | ADIR (FR) | 1998-05-20 | — | — | CN | disclosed |
| US-RE29834-E | PREPARED FROM 4-SULFONYL-1,8-NAPHTHOLACTAMS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-11-14 | — | — | US | disclosed |
| US-3959310-A | BENZINDOLE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124674-A1 | 5/5-OR 5/6-MEMBERED CONDENSED RING CYCLOALKYLAMINE DERIVATIVE | MCHR1, MC5R, MCHR2 | KMT2A 1001/4885CA12 3995/4885CA9 2808/4885 |
| US-20080262035-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC11 | KMT2A 51/4885CA12 1383/4885CA9 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.