Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479658 | 0.95 | FGFR4 (0.45) | ABL1MAPK1SMN1; SMN2FGFR4RAB9A | |
| SCHEMBL4479659 | 0.92 | ABL1 (0.52) | ABL1MAPK1SMN1; SMN2FGFR4RAB9A | |
| SCHEMBL4483127 | 0.88 | TNK2 (0.52) | ABL1SMN1; SMN2FGFR4RAB9ANPC1 | |
| SCHEMBL4479243 | 0.88 | TNK2 (0.54) | ABL1SMN1; SMN2FGFR4RAB9ANPC1 | |
| SCHEMBL4492344 | 0.81 | TNK2 (0.54) | ABL1FGFR4BCRTNK2MAP4K2 | |
| SCHEMBL4478660 | 0.79 | TNK2 (0.56) | ABL1MAPK1SMN1; SMN2FGFR4RAB9A | |
| SCHEMBL4486681 | 0.79 | TNK2 (0.52) | ABL1SMN1; SMN2FGFR4LMNABCR | |
| SCHEMBL4467325 | 0.77 | TNK2 (0.61) | ABL1SMN1; SMN2FGFR4LMNAMAPT | |
| SCHEMBL4469297 | 0.77 | TNK2 (0.58) | ABL1FGFR4BCRTNK2MAP4K2 | |
| SCHEMBL3580197 | 0.75 | FGFR4 (0.40) | ABL1FGFR4LMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080032970-A1 | Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | HOFFMANN-LA ROCHE INC. | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032970-A1 | Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | DPYD, GART, DDC | ABL1 440/4885MAPK1 2399/4885SMN1; SMN2 3861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.