Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | APLNR | P35414 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916458 | 0.91 | TSHR (0.56) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4922782 | 0.90 | TSHR (0.55) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4926169 | 0.89 | TSHR (0.55) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4913986 | 0.89 | TSHR (0.54) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4920750 | 0.88 | TSHR (0.53) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4923572 | 0.88 | TSHR (0.53) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4921760 | 0.88 | TSHR (0.55) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4916465 | 0.87 | TSHR (0.56) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4924366 | 0.86 | TSHR (0.51) | HTR2ATSHROPRM1ABCB11CYP1A2 | |
| SCHEMBL4924079 | 0.86 | TSHR (0.55) | HTR2ATSHROPRM1ABCB11CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081824-A1 | Substituted piperidines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY | 2008-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081824-A1 | Substituted piperidines as modulators of chemokine receptor activity | CCR1, CCR3, CCR2 | HTR2A 1435/4885TSHR 727/4885OPRM1 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.